Nothing's worse than someone you trust stabbing you in the back, and Albert Wesker is the ultimate betrayer in the survival horror franchise Resident Evil. Once the team leader of an elite unit called S.T.A.R.S., he willingly led his team into the path of a deadly virus to suit his own purposes. Not content with this betrayal, or to have the good sense to just die like he leads you to believe at the end of the first Resident Evil, Wesker has returned time and again throughout the series to torment the many people whose lives were affected by the virus he helped set loose.
Through the many years and games he's become more and more evil thanks to the T-Virus he infected himself with in order to survive the mortal wounds he suffered in the first Resident Evil. Imbued with superhuman strength and endurance, Wesker has moved from being a double-agent working to kill his own team, to an evil-tyrant seeking to infect the world with a virus that will turn them into zombies.
http://www.ign.com/videogame-villains/14.html
Though he's running around the globe with a gun and a pretty journalist sidekick, somehow the Uncharted series' cocky protagonist Nathan Drake still feels like your mate. You know, the one who irregularly comes back home with a face full of bruises, a body full of bullets and a sea chest full of gold. You know, that one. The one who can climb almost anything. That guy.
Though his day job is lobbing grenades around ancient ruins, firing AK-47s from the top of Himalayan mountains and desecrating World Heritage Sites, he does it with a genuine sense of self-awareness, pointing out how ridiculous it is and dropping genuinely hilarious wisecracks - all in a pair of jeans and a t-shirt (half out, half tucked).
Simply put, Nate's a charming son of a bitch and the gaming character we'd most like to go out drinking with - an accolade we don't bestow lightly.
http://www.empireonline.com/features/50-greatest-video-game-characters/default.asp?film=22
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